Influence of Physical Activity Levels and Functional Capacity on Brain β-Amyloid Deposition in Older Women

R Pedrero-Chamizo; C Szoeke; L Dennerstein; S Campbell

Journal article

Influence of Physical Activity Levels and Functional Capacity on Brain β-Amyloid Deposition in Older Women

R Pedrero-Chamizo, C Szoeke, L Dennerstein, S Campbell

Frontiers in Aging Neuroscience | Published : 2021

DOI: 10.3389/fnagi.2021.697528

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Abstract

Physical activity (PA) and Alzheimer's disease are associated. However, how PA influences the cerebral β-amyloid (Aβ) burden remains unclear. The aim of this study was to determine if PA levels and/or functional capacity (FC) are associated with Aβ plaque deposition, and whether these associations differed according to APOE-ε4 genotype. A total of 117 women (69.7 ± 2.6 years; 33.3% APOE-ε4-carriers) from the Women's Healthy Ageing Project cohort (WHAP) were analyzed. PA was measured using the International Physical Activity Questionnaire and, FC was evaluated using the Timed Up and Go test (TUGt). Positron emission tomography with F-18 Florbetaben was carried out to assess cerebral Aβ burden..

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University of Melbourne Researchers

Cassandra Szoeke Author

Lorraine Dennerstein Author

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Awarded by Alzheimer's Association

Funding Acknowledgements

Funding for the Healthy Aging Program (HAP) has been provided by the National Health and Medical Research Council [NHMRC grants 547600, 1032350, and 1062133], Ramaciotti Foundation, Australian Healthy Aging Organisation, the Brain Foundation, the Alzheimer's Association [NIA320312], and Australian Menopausal Society, Bayer Healthcare, Shepherd Foundation, Scobie and Claire Mackinnon Foundation, Collier Trust Fund, J.O. & J.R. Wicking Trust, Mason Foundation, the Alzheimer's Association of Australia and Royal Australian College of Physicians. Inaugural funding was provided by VicHealth and the NHMRC. The Principal Investigator of HAP (CS) is supported by the National Health and Medical Research Council. RP-C was supported by Spanish Ministry of Education under Programa Estatal de Promocion del Talento y su Empleabilidad en I+D+i, Subprograma Estatal de Movilidad, del Plan Estatal de Investigacion Cientifica y Tecnica y de Innovacion 2013-2016 [CAS18/00457]. The content of this paper is the responsibility of the authors. The funders did not take any part in this work.